1426545-24-5Relevant articles and documents
An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors
Zhang, Wen,Sviripa, Vitaliy M.,Kril, Liliia M.,Yu, Tianxin,Xie, Yanqi,Hubbard, W. Brad,Sullivan, Patrick G.,Chen, Xi,Zhan, Chang-Guo,Yang-Hartwich, Yang,Evers, B. Mark,Spear, Brett T.,Gedaly, Roberto,Watt, David S.,Liu, Chunming
, p. 11348 - 11358 (2019)
The importance of upregulated Wnt signaling in colorectal cancers led to efforts to develop inhibitors that target β-catenin in this pathway. We now report that several "Wnt inhibitors" that allegedly target β-catenin actually function as mitochondrial pr