1426549-96-3

Upstream product

• 1426549-95-2 4-azido-2,3,5-tri-O-benzyl-4-deoxy-L-arabinitol 
• 1426549-94-1 4-azido-2,3,5-tri-O-benzyl-4-deoxy-1-O-trityl-L-arabinitol 
• 1426549-93-0 2,3,5-tri-O-benzyl-4-methanesulfonyl-1-O-trityl-D-xylitol 
• 1426549-92-9 2,3,5-tri-O-benzyl-1-O-trityl-D-xylitol 
• 100896-16-0 2,3,5-tri-O-benzyl-D-xylitol 
• 16838-89-4 2,3,5-tri-O-benzyl-D-xylofuranose 

Downstream Products

• 1426550-08-4 pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-L-idohexonamide 
• 1426550-07-3 pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-L-gulohexonamide 
• 1426550-06-2 1,1,3,3-tetramethylbutyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-L-idohexonamide 
• 1426550-05-1 1,1,3,3-tetramethylbutyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-L-gulohexonamide 
• 1426550-04-0 5-(adamantan-1-yl-methoxy)pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-L-idohexonamide 
• 1426550-03-9 5-(adamantan-1-yl-methoxy)pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-L-gulohexonamide 
• 1426550-02-8 pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-(pent-4-enimido)-L-idohexonamide 
• 1426550-01-7 pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-(pent-4-enimido)-L-gulohexonamide 
• 1426550-00-6 1,1,3,3-tetramethylbutyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-(pent-4-enimido)-L-idohexonamide 
• 1426549-99-6 1,1,3,3-tetramethylbutyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-(pent-4-enimido)-L-gulo-hexonamide 
• 1426549-98-5 5-(adamantan-1-yl-methoxy)pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-(pent-4-enimido)-L-idohexonamide 
• 1426549-97-4 5-(adamantan-1-yl-methoxy)pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy2,5-(pent-4-enimido)-L-gulohexonamide 

Relevant academic research and scientific papers

The development of an aza-C-glycoside library based on a tandem staudinger/aza-wittig/ugi three-component reaction

We report the tandem Staudinger/aza-Wittig/Ugi three-component reaction mediated synthesis of a 64-member compound library of aza-C-glycosides. The library is composed of four pyrrolidine and three piperidine scaffolds, onto which a number of functional groups is grafted to form seven sublibraries. Variation in the library is achieved by transformation of two pentoses and a hexose into the corresponding 4-azidopentanal and 5-azidohexanal derivatives as precursors for the Staudinger/aza-Wittig process. Further variation is achieved by using different isocyanides as well as protective- and functional-group manipulations on the fully protected Ugi-3CR intermediates. Preliminary biological evaluation of the compound library revealed several low micromolar inhibitors of human acid glucosylceramidase.