1426575-53-2

Upstream product

• 103-80-0 phenylacetyl chloride 
• 75-61-6 dibromodifluoromethane 

Downstream Products

• 1426575-44-1 (2Z)-2-benzylidene-5-fluoro-3,3-dimethyl-2,3-dihydrofuran 
• 1629870-89-8 N-(1-benzyl-4,4-difluoro-2,2-dimethylbut-3-en-1-ylidene)-4-methylbenzenesulfonamide 
• 1629870-98-9 (2E)-2-benzylidene-5-fluoro-3,3-dimethyl-1-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole 

Relevant academic research and scientific papers

Nucleophilic 5-endo-trig cyclization of 3,3-difluoroallylic ketone enolates: Synthesis of 5-fluorinated 2-alkylidene-2,3-dihydrofurans

3,3-Difluoroallylic ketones readily undergo nucleophilic 5-endo-trig cyclization through their metal enolates to afford 5-fluorinated 2-alkylidene-2,3-dihydrofurans. O-Cyclization exclusively occurred via intramolecular substitution of the vinylic fluorin

Nucleophilic 5- Endo - Trig cyclization of 3,3-difluoroallylic metal enolates and enamides: Facile synthesis of ring-fluorinated dihydroheteroles

Metal enolates and enamides bearing difluoroallylic moieties underwent nucleophilic 5-endo-trig cyclization, a process considered to be disfavored according to Baldwin's rules. Whereas no C-cyclization was observed in these reactions, O- and N-cyclization proceeded exclusively to afford 5-fluorinated 2-alkylidene-2,3-dihydrofurans and -2,3-dihydropyrroles, respectively. Georg Thieme Verlag Stuttgart New York.