1426581-38-5

Basic information

• Product Name: 4-{1-[2-(4-bromophenyl)-2-oxo-ethyl]-1H-[1,2,3]triazol-4-ylmethoxy}-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester
• Synonyms: 4-{1-[2-(4-bromophenyl)-2-oxo-ethyl]-1H-[1,2,3]triazol-4-ylmethoxy}-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester
• CAS NO: 1426581-38-5
• Molecular Weight: 563.331
• Mol File: 1426581-38-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{1-[2-(4-bromophenyl)-2-oxo-ethyl]-1H-[1,2,3]triazol-4-ylmethoxy}-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{1-[2-(4-bromophenyl)-2-oxo-ethyl]-1H-[1,2,3]triazol-4-ylmethoxy}-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester(1426581-38-5)
• EPA Substance Registry System: 4-{1-[2-(4-bromophenyl)-2-oxo-ethyl]-1H-[1,2,3]triazol-4-ylmethoxy}-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester(1426581-38-5)

Safety Data

• Hazardous Substances Data: 1426581-38-5(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 23779-94-4 2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester 
• 1429232-10-9 4-prop-2-ynyloxy-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester 
• 99-73-0 para-bromophenacyl bromide 

Relevant articles and documents

Click chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents

Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6.