1426689-23-7Relevant articles and documents
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule
Poslusney, Michael S.,Melancon, Bruce J.,Gentry, Patrick R.,Sheffler, Douglas J.,Bridges, Thomas M.,Utley, Thomas J.,Daniels, J. Scott,Niswender, Colleen M.,Conn, P. Jeffrey,Lindsley, Craig W.,Wood, Michael R.
, p. 1860 - 1864 (2013/04/10)
This Letter describes the further optimization of an MLPCN probe molecule (ML137) through the introduction of 5- and 6-membered spirocycles in place of the isatin ketone. Interestingly divergent structure-activity relationships, when compared to earlier M