142677-15-4 Usage
General Description
Irinotecan Hydroxyl Acid is a metabolite of the cancer-fighting drug irinotecan, commonly used in the treatment of colorectal cancer. It is an active metabolite that is formed in the liver and has been found to be more potent and less toxic than the parent drug. Irinotecan Hydroxyl Acid works by inhibiting the enzyme topoisomerase I, which plays a crucial role in DNA replication and repair. This disruption in DNA function leads to the death of cancer cells, making it an important component in the treatment of various types of cancer. However, it can also cause side effects such as diarrhea, nausea, and vomiting.
Check Digit Verification of cas no
The CAS Registry Mumber 142677-15-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,7 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 142677-15:
(8*1)+(7*4)+(6*2)+(5*6)+(4*7)+(3*7)+(2*1)+(1*5)=134
134 % 10 = 4
So 142677-15-4 is a valid CAS Registry Number.
142677-15-4Relevant articles and documents
Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT-11 and SN-38, in aqueous solution
Akimoto,Kawai,Ohya
, p. 2135 - 2138 (1994)
The effect of pH and temperature on the reaction rate of the hydrolysis and lactonization of camptothecin and its derivatives, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) and 7-ethyl-10-hydroxycamptothecin (SN-38), in aqueous solution was studied by high-performance liquid chromatography or two-wavelength spectrophotometry. Hydrolysis and lactonization of each compound progressed according to pH- and temperature-dependent pseudo-first-order kinetics. The ratio of the lactone form of each compound to its hydroxy-acid form was determined mainly by the pH of the solution and was not influenced by temperature. Half-lives of the lactone and hydroxy-acid forms of CPT-11 at 37°C and pH 7.4 were 13.7 min and 4.25 h, respectively.
