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142678-35-1

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142678-35-1 Usage

General Description

S-Pantoprazole is a proton pump inhibitor (PPI) that works by reducing the amount of acid produced in the stomach. It is prescribed to treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excessive stomach acid production. S-Pantoprazole is a form of the drug pantoprazole that is the active enantiomer of the compound, and it is often used in the treatment of acid-related disorders due to its higher potency and quicker onset of action compared to the racemic mixture. It is typically taken orally, and common side effects may include headache, diarrhea, and nausea. S-Pantoprazole is available by prescription and should be used under the guidance of a healthcare professional.

Check Digit Verification of cas no

The CAS Registry Mumber 142678-35-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,7 and 8 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 142678-35:
(8*1)+(7*4)+(6*2)+(5*6)+(4*7)+(3*8)+(2*3)+(1*5)=141
141 % 10 = 1
So 142678-35-1 is a valid CAS Registry Number.

142678-35-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (-)-pantoprazole

1.2 Other means of identification

Product number -
Other names (S)-pantoprazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:142678-35-1 SDS

142678-35-1Downstream Products

142678-35-1Relevant articles and documents

Biphasic recognition chiral extraction - Novel way of separating pantoprazole enantiomers

Liu, Jia-Jia,Liu, Chang,Tang, Ke-Wen,Zhang, Pan-Liang

, p. 599 - 607 (2014)

This paper presents a biphasic recognition chiral extraction system developed as a new chiral separation technology for the separation of pantoprazole enantiomers, combining a hydrophilic β-CD derivative in the aqueous phase and a hydrophobic tartaric acid in the organic phase which preferentially recognise the (R)-enantiomer and (S)-enantiomer, respectively. In this study, a number of factors which influence the efficiency of the extraction were investigated including types of organic solvents, β-CD and tartaric acid esters and their concentrations, pH and temperature. As a result, enantioselectivity for pantoprazole enantiomers can be improved up to 1.42 under optimised conditions; in addition, it is clear that the combined action of β-CD and tartaric acid esters leads to formation of the biphasic chiral extraction system with a stronger separation capacity than a monophasic chiral extraction system.

Method for preparing chiral sulfoxide drugs in water phase

-

Paragraph 0053-0055, (2020/09/09)

The invention relates to the field of chiral drug preparation, in particular to a method for preparing chiral sulfoxide drugs in a water phase. The method for preparing the chiral sulfoxide drugs in the water phase comprises the following steps: using a hydrogen peroxide solution as oxidant, using a temperature-sensitive ferrocene chiral amino acid titanium complex as a catalyst and using prochiral thioether as a substrate in the pure water phase to perform an asymmetric oxidation reaction to synthesize the chiral sulfoxide drugs. The temperature-sensitive ferrocene chiral amino acid titaniumcomplex catalyst can be utilized to catalyze the asymmetric oxidation reaction of thioether in the pure water phase and has the characteristics of high catalytic efficiency and easy recovery of the catalyst.

Synthesis of Esomeprazole and Related Proton Pump Inhibitors through Iron-Catalyzed Enantioselective Sulfoxidation

Nishiguchi, Shigenobu,Izumi, Takuhiro,Kouno, Takayoshi,Sukegawa, Junpei,Ilies, Laurean,Nakamura, Eiichi

, p. 9738 - 9743 (2018/10/09)

We report here an application of iron catalysis for the kilogram scale asymmetric synthesis of a proton pump inhibitor, esomeprazole, in 87% yield and 99.4% ee by catalytic sulfoxidation with hydrogen peroxide using an iron salt/chiral Schiff base in combination with a carboxylate salt. Under similar reaction conditions, other proton pump inhibitors such as (S)-lansoprazole, (S)-rabeprazole, and (S)-pantoprazole, were also synthesized in high yield and ee. A carboxylate additive was crucial for the success of this reaction, and we consider that it coordinates to the active iron species, and it also acts as a hydrogen-bond acceptor to coordinate to the substrate through the imidazole NH.

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