142678-92-0Relevant articles and documents
Cyclic alpha-dehydroamino ketones, chiral cyclic alpha-amino ketone and preparation method thereof
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, (2017/04/20)
The invention provides cyclic alpha-dehydroamino ketones, chiral cyclic alpha-amino ketone and a preparation method of the chiral cyclic alpha-amino ketone. The preparation method comprises the following steps: enabling the cyclic alpha-dehydroamino ketones as shown in a general formula (1) to react in an organic solvent at a hydrogen atmosphere under the catalytic effect of diphosphine-rhodium complex to obtain the chiral cyclic alpha-amino ketone as shown in a general formula (2). The preparation method adopts an asymmetric catalytic hydrogenation, is simple and effective in process, and is suitable for industrial large-scale production. The product, chiral amino ketone, prepared according to the method can be further derived into chiral amino ketone alcohol ligand and chiral amino medicine intermediate, thus having wide application in the industry.
Cyclic trans-β-amino alcohols: Preparation and enzymatic kinetic resolution
Rouf, Abdul,Gupta, Pankaj,Aga, Mushtaq A.,Kumar, Brijesh,Parshad, Rajinder,Taneja, Subhash C.
, p. 2134 - 2143 (2012/05/04)
Enantioenriched cyclic β-amino alcohols, trans-2-aminocyclohexanols (ee, >99%), trans-2-aminocyclopentanols (ee, >99%), trans-1-amino-2- indanols (ee, >99%) and trans-2-amino-1-indanols (ee, ~98%) were prepared in high yields via an Arthrobacter sp. Lipase/PLAP catalyzed kinetic resolution of racemic phthalimido acetates. The addition of toluene as a co-solvent dramatically improved the hydrolysis and enantioselectivity, whereas for indanols, substrate immobilization on Celite improved the efficacy of the kinetic resolution.
Efficient synthesis of a chiral mediator
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, (2008/06/13)
An efficient method for the quantitative preparation and isolation of a compound of formula I STR1 or its enantiomer, a chiral mediator used in enantioselective synthesis.