142685-25-4

Basic information

• Product Name: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE
• Synonyms: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE;2,3,5,6-Tetrafluorophenyl trifluoroacetate 98%;2,3,5,6-Tetrafluorophenyltrifluoroacetate98%;Trifluoroacetic acid 2,3,5,6-tetrafluorophenyl ester, 2,3,5,6-Tetrafluorophenyl 2,2,2-trifluoroethanoate;2,3,5,6-Tetrafluorophenyl 2,2,2-trifluoroacetate
• CAS NO: 142685-25-4
• Molecular Formula: C₈HF₇O₂
• Molecular Weight: 262.08
• Mol File: 142685-25-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 145.996°C at 760 mmHg
• Flash Point: 41.681°C
• Appearance: /
• Density: 1.635g/cm³
• Vapor Pressure: 4.734mmHg at 25°C
• Refractive Index: 1.39
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE(142685-25-4)
• EPA Substance Registry System: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE(142685-25-4)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 142685-25-4(Hazardous Substances Data)

Usage

General Description

2,3,5,6-Tetrafluorophenyl trifluoroacetate is a chemical compound with the molecular formula C8H2F7O2. It is an organofluorine compound that contains four fluorine atoms attached to a phenyl ring and three fluorine atoms attached to the acetyl group. This chemical is a colorless liquid with a pungent odor, and it is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a solvent in organic reactions and as a reagent in the fluorination of organic compounds. Additionally, 2,3,5,6-Tetrafluorophenyl trifluoroacetate is a highly reactive compound and should be handled with caution due to its potential for causing skin and eye irritation.

InChI:InChI=1/C8HF7O2/c9-2-1-3(10)5(12)6(4(2)11)17-7(16)8(13,14)15/h1H

Upstream product

• 769-39-1 2,3,5,6-tetraflourophenol 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 905575-65-7 perfluorophenyl 4,20-dioxo-24-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-9,12,15-trioxa-5,19-diazatetracosan-1-oate 
• 158041-85-1 2,3,4,6-tetra-O-acetylgalactopyranosyl-1-α-(3'-thiopropionate-O-2,3,5,6-tetrafluorophenyl ester) 
• 295322-45-1 C₂₄H₂₉F₄N₃O₆S 
• 944251-26-7 C₁₅H₈F₄O₃ 
• 915944-73-9 nitromethane-tris(3-propionate-O-2,3,5,6-tetrafluorophenyl ester) 
• 183896-00-6 N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide 
• 852178-15-5 C₁₄H₁₄F₄NO₆S₂^(1-)*Na⁽¹⁺⁾ 
• 852178-14-4 2,3,5,6-tetrafluorophenoxycarbonylmethyl thiosulfate N,N-diisopropylethylamine salt 
• 195152-91-1 3-(biotinamido)butyrate tetraflulorophenyl ester 
• 173341-32-7 biotin 2,3,5,6-tetrafluorophenyl ester 

Relevant articles and documents

In situ monitoring of bindings between dasatinib and its target protein kinases using magnetic nanoparticles in live cells

We report a novel technology, called In Cell IT, for in situ monitoring of bindings between a small molecule kinase inhibitor and its target protein kinases in live cells using a kinase inhibitor, dasatinib, as a model compound. Streptavidin-attached MNPs were coated by biotinylated dasatinib, and then these dasatinib-MNPs were transferred into cells. In the cells, the MNPs were aligned to the same direction of the magnetic field and EGFP-tagged target protein kinases were bound to dasatinib-MNPs. Using this technology, we demonstrated the bindings between dasatinib and its target protein kinases including SRC, ABL1, and CSK in live cells. The specificity of these bindings was also confirmed by cold competition using unbiotinylated dasatinib in the same cells. Copyright

Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia

[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide ([18F]-EF3) has been prepared, in 65% chemical yield and 5% radiochemical yield, by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate 1 with [18F]-3,3,3-trifluoropropylamine 7. This original radiolabelled key-synthon was obtained in 40% overall chemical yield by oxidative [18F]-fluorodesulfurization of ethyl N-phthalimido-3-aminopropane dithioate 4, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine 5. All the process was performed within 90min, from the [18F]-HF production in the cyclotron to the purification of the final target. Copyright

Selective binding complementary oligonucleotides

In a matched pair of oligonucleotides (ODNS) each member of the pair is complementary or substantially complementary in the Watson Crick sense to a target sequence of duplex nucleic acid where the two strands of the target sequence are themselves compleme