142688-28-6

Basic information

• Product Name: 5-broMo-3-iodo-1-tosyl-1H-indole
• Synonyms: 5-broMo-3-iodo-1-tosyl-1H-indole
• CAS NO: 142688-28-6
• Molecular Formula: C₁₅H₁₁BrINO₂S
• Molecular Weight: 476
• Mol File: 142688-28-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-broMo-3-iodo-1-tosyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-3-iodo-1-tosyl-1H-indole(142688-28-6)
• EPA Substance Registry System: 5-broMo-3-iodo-1-tosyl-1H-indole(142688-28-6)

Safety Data

• Hazardous Substances Data: 142688-28-6(Hazardous Substances Data)

Usage

General Description

5-bromo-3-iodo-1-tosyl-1H-indole is a chemical compound with the chemical formula C16H11BrINO2S. It is a derivative of indole, a heterocyclic compound. 5-broMo-3-iodo-1-tosyl-1H-indole contains a bromine atom, an iodine atom, and a tosyl group attached to the indole ring. It is commonly used in organic synthesis and medicinal chemistry as a building block for the production of various pharmaceuticals and bioactive compounds. Its unique structure and reactivity make it a valuable intermediate in the synthesis of diverse organic molecules for applications in drug discovery and development.

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 868694-19-3 5-bromo-3-iodo-1H-indole 

Relevant articles and documents

Efficient salt-induced kinase inhibitor and preparation method thereof

The invention discloses an efficient salt-induced kinase inhibitor and a preparation method thereof, and the efficient salt-induced kinase inhibitor is characterized by comprising substances of a chemical formula in the invention. The salt-induced kinase inhibitor with excellent performance has high inhibitory activity for in-vitro experiments and also has high cell inhibitory activity.

Enantioselective Synthesis of Cyclohepta[ b]indoles via Pd-Catalyzed Cyclopropane C(sp3)-H Activation as a Key Step

An enantioselective synthesis of functionalized cyclohepta[b]indoles via Pd-catalyzed cyclopropane C-H activation followed by olefination and indole-vinylcyclopropane rearrangement is reported. The design of the chiral cyclopropane precursor was such that both enantiomeric cyclohepta[b]indoles were accessed from a single compound exhibiting a "hidden" symmetry plane. The scope of the method was demonstrated by varying the substituents on the cyclopropane as well as on the heterocycle itself.

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.