1426892-06-9Relevant academic research and scientific papers
Copper-catalyzed debenzoylative monofluoromethylation of aryl iodides assisted by the removable (2-Pyridyl)sulfonyl group
Zhao, Yanchuan,Ni, Chuanfa,Jiang, Fanzhou,Gao, Bing,Shen, Xiao,Hu, Jinbo
, p. 631 - 634 (2013/05/09)
A new method for aromatic monofluoromethylation was developed. Aryl iodides can be efficiently transformed into the corresponding monofluoromethylated products by a copper-catalyzed debenzoylative fluoroalkylation with 2-PySO 2CHFCOR and subsequent reductive desulfonylation. The (2-pyridyl)sulfonyl moiety plays an important role in the copper-catalyzed cross-coupling, and it can be removed easily through Bu3SnH-mediated desulfonylation.
