1426892-09-2Relevant academic research and scientific papers
Reagent for preparing high-selectivity monofluoroolefin
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Paragraph 0148-0150; 0155-0159, (2021/09/04)
The invention provides a reagent for preparing high-selectivity monofluoroolefin, particularly a reagent capable of preparing monofluoroolefin at high selectivity and a method for preparing monofluoroolefin by using the reagent. The method has the advanta
Spontaneous resolution of julia-kocienski intermediates facilitates phase separation to produce Z - And e -monofluoroalkenes
Zhao, Yanchuan,Jiang, Fanzhou,Hu, Jinbo
supporting information, p. 5199 - 5203 (2015/05/05)
The monofluoroalkene motif is important in drug development as it serves as a peptide bond isostere and is found in a number of biologically active compounds with various pharmacological activities. Direct olefination of carbonyl compound is a straightfor
Copper-catalyzed debenzoylative monofluoromethylation of aryl iodides assisted by the removable (2-Pyridyl)sulfonyl group
Zhao, Yanchuan,Ni, Chuanfa,Jiang, Fanzhou,Gao, Bing,Shen, Xiao,Hu, Jinbo
, p. 631 - 634 (2013/05/09)
A new method for aromatic monofluoromethylation was developed. Aryl iodides can be efficiently transformed into the corresponding monofluoromethylated products by a copper-catalyzed debenzoylative fluoroalkylation with 2-PySO 2CHFCOR and subsequent reductive desulfonylation. The (2-pyridyl)sulfonyl moiety plays an important role in the copper-catalyzed cross-coupling, and it can be removed easily through Bu3SnH-mediated desulfonylation.
