1426961-60-5

Basic information

• Product Name: (3S,4R)-4-(2-chloro-6-(4-fluorophenyl)pyridin-4-yl)-3-ethyl-3-phenyloxetan-2-one
• CAS NO: 1426961-60-5
• Molecular Weight: 381.834
• Mol File: 1426961-60-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,4R)-4-(2-chloro-6-(4-fluorophenyl)pyridin-4-yl)-3-ethyl-3-phenyloxetan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-4-(2-chloro-6-(4-fluorophenyl)pyridin-4-yl)-3-ethyl-3-phenyloxetan-2-one(1426961-60-5)
• EPA Substance Registry System: (3S,4R)-4-(2-chloro-6-(4-fluorophenyl)pyridin-4-yl)-3-ethyl-3-phenyloxetan-2-one(1426961-60-5)

Safety Data

• Hazardous Substances Data: 1426961-60-5(Hazardous Substances Data)

Upstream product

• 36854-57-6 2-Phenylbutyryl chloride 
• 20452-67-9 phenylethylketene 
• 881402-42-2 C₁₂H₇ClFNO 

Relevant articles and documents

NHC-promoted asymmetric β-lactone formation from arylalkylketenes and electron-deficient benzaldehydes or pyridinecarboxaldehydes

A chiral NHC catalyzes the asymmetric formal [2 + 2] cycloaddition of alkylarylketenes with both electron-deficient benzaldehydes and 2- and 4-pyridinecarboxaldehydes to generate stereodefined β-lactones. In the benzaldehyde series, optimal product diastereo- and enantiocontrol is observed using 2-nitrobenzaldehyde (up to 93:7 dr (syn:anti) and 93% ee). Substituted 2- and 4-pyridinecarboxaldehydes are also tolerated in this process, generating the corresponding β-lactones in good yield and enantioselectivity, although the diastereocontrol in these processes is highly dependent upon the aldehyde substitution. These processes are readily scalable, allowing multigram quantities of the β-lactone products to be prepared. Derivatization of these products, either through ring opening into the corresponding stereodefined β-hydroxy and β-amino acid derivatives without loss of stereochemical integrity or via cross-coupling, is demonstrated.