1426962-01-7Relevant academic research and scientific papers
Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones
Olimpio Da Silva, Adriano,Da Silva Lopes, Rosangela,Vieira De Lima, Ricardo,Santos Suniga Tozatti, Camila,Marques, Maria Rita,De Albuquerque, Sergio,Beatriz, Adilson,Pires De Lima, Denis
, p. 51 - 56 (2013)
The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3- hydroxynaphthalene-1,4-dione (9) with IC50 of 7.8 μM.
