142697-70-9Relevant articles and documents
Novel practical deprotection of N-Boc compounds using fluorinated alcohols
Choy, Jason,Jaime-Figueroa, Saul,Jiang, Laurence,Wagner, Paul
, p. 3840 - 3853 (2008/12/23)
The thermolytic deprotection of N-Boc compounds was accomplished using TFE (2,2,2-trifluoroethanol) or HFIP (hexafluoroisopropanol) as solvents. Even though the cleavage of the t-butylcarbamate (Boc) group can be achieved at solvent reflux temperature, the deprotection process was significantly accelerated under microwave-assisted conditions. The practicality of this methodology was demonstrated on alkyl, aryl, and heteroaromatic N-Boc-amines. Copyright Taylor & Francis Group, LLC.