1427-34-5

Usage

Synonyms

p-[[1-(1-chloro-2,2,2-trifluoroethyl)phenyl]methoxy]benzene

Functional groups

Chlorine atom
Trifluoromethyl group
Methoxy group

Structural features

Benzene ring
Chlorine atom attached to one carbon
Trifluoromethyl group attached to the same carbon as the chlorine atom
Methoxy group attached to another carbon

Classification

Halogenated aromatic compound

Applications

Synthesis of pharmaceuticals
Synthesis of agrochemicals
Solvent in industrial processes

Safety precautions

Harmful if ingested or inhaled
May cause skin and eye irritation
Handle with caution

Upstream product

• 104395-40-6 C₉H₈F₃O⁽¹⁺⁾ 
• 300373-86-8 2,2,2-trifluoro-1-(4-methoxyphenyl)-1-ethanone O-(p-tolylsulfonyl)oxime 
• 891501-19-2 3-(4-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine 
• 1346414-73-0 para-methoxyphenyl(trifluoromethyl)carbene 
• 17556-42-2 2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol 
• 104395-38-2 Methanesulfonic acid 2,2,2-trifluoro-1-(4-methoxy-phenyl)-ethyl ester 

Downstream Products

• 104395-40-6 C₉H₈F₃O⁽¹⁺⁾ 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 24812-20-2 3,4,5-trimethylbenzyl chloride 

Relevant academic research and scientific papers

Efficiency synthesis of compounds with trifluoromethyl benzyl halide structure catalyzed by nickel salt and conversion application thereof

The invention discloses efficiency synthesis of compounds with trifluoromethyl benzyl halide structure catalyzed by a nickel salt and conversion application thereof. The method is to synthesize the compound of formula C from the compound of formula A1 or A2 and the compound of formula B under the catalysis of the nickel salt and in the presence of a basic compound and/or ligand. The definition ofthe compound is shown in the specification. The method has the advantages of simple and easily available raw materials, less catalyst dosage, wide substrate application range, simple operation, high reaction efficiency and the like, and the prepared product can be further converted into various important trifluoromethyl-containing compounds which are widely applied in aspects of biomedicine, pesticide, material science and the like.

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

A Stille cross-coupling reaction was developed that delivers for the first time trifluoromethyl-substituted homoallyl compounds from α-(trifluoromethyl)benzyl chlorides and allylstannanes. This reaction proceeds even with low catalyst loadings (1 mol%) vi

Regiochemical substituent switching of spin states in aryl(trifluoromethyl) carbenes

Although aryl(trifluoromethyl)diazirines have achieved great popularity in photoaffinity labeling applications, the properties of the corresponding carbenes have not been as widely explored. Here, low-temperature matrix-isolation spectroscopy and reactivi

An efficient dehyrohalogenation method for the synthesis of α,β,β-trifluorostyrenes, α-chloro-β,β- difluorostyrenes and E-1-arylperfluoroalkenes

Dehydrofluorination of 1-aryl-1,2,2,2-tetrafluoroethanes (ArCHFCF 3) and 1-aryl-1-chloro-2,2,2-trifluoroethane (ArCHClCF3) using lithiumhexamethyldisilazide (LHMDS) in tetrahydrofuran (THF) at room temperature produced 1,2,2-trifluorostyrene and 1-chloro-2,2-difluorostyrene, respectively, in very good isolated yields. Dehydrofluorination of 1,2,2,3,3,3-hexafluoro-1-phenyl-propane (PhCHFCF2CF3) and 1,2,2,3,3,4,4,4-octafluoro-1-phenyl-butane (PhCHFCF2CF 2CF3) using LHMDS produced the corresponding substituted olefins (1-phenyl-1,2,3,3,3-pentafluoroprop-1-ene and 1-phenyl-1,2,3,3,4,4,4- pentafluorobut-1-ene) in good yield and high E-selectivity. Dehydrofluorination of 1-chloro-1-phenyl-2,2,3,3,3-pentafluoropropane (PhCHClCF2CF 3) and 1-chloro-1-phenyl-2,2,3,3,4,4,4-heptafluorobutane (PhCHClCF2CF2CF3) produced a mixture of the corresponding E and Z olefins (PhCClCFCF3 and PhCClCFCF 2CF3) in good yield.

Fungicidial compounds having a fluorovinyloxphyenyl moiety and process for the preparation thereof

A fungicidal compound of formula (I) having a fluorovinyloxyphenyl moiety and stereoisomers thereof are useful for protecting crops from fungal diseases: wherein: X is CH or N; Y is O or S; Z is O or NH; R1is hydrogen or CF3; and R2is hydrogen, a C1-10alkyl, naphthyl, thiophenyl or a phenyl group optionally carrying one or more substituents selected from the group consisting of C1-6alkyl, halogen-substituted C1-6alkyl, C1-6alkoxy, phenoxy, halogen, and methylenedioxy radicals.

The effect of β-fluorine substituents on the rate and equilibrium constants for the reactions of α-substituted 4-methoxybenzyl carbocations and on the reactivity of a simple quinone methide

The reactions of 4-MeOArCH(R)Cl (R = CH2F, CHF2, CF3) and 4-MeOArC(CF3)2Y (Y = OTs and Br) with nucleophilic reagents were studied in 50:50 (v/v) trifluoroethanol/water. There is chloride common ion r