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CAS

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1427043-08-0

(3R,5R,6S)-5,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)morpholin-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1427043-08-0 Structure

  • Basic information

    1. Product Name: (3R,5R,6S)-5,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)morpholin-2-one
    2. Synonyms: (3R,5R,6S)-5,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)morpholin-2-one
    3. CAS NO:1427043-08-0
    4. Molecular Formula:
    5. Molecular Weight: 546.558
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1427043-08-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3R,5R,6S)-5,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)morpholin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3R,5R,6S)-5,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)morpholin-2-one(1427043-08-0)
    11. EPA Substance Registry System: (3R,5R,6S)-5,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)morpholin-2-one(1427043-08-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1427043-08-0(Hazardous Substances Data)

1427043-08-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1427043-08-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,0,4 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1427043-08:
(9*1)+(8*4)+(7*2)+(6*7)+(5*0)+(4*4)+(3*3)+(2*0)+(1*8)=130
130 % 10 = 0
So 1427043-08-0 is a valid CAS Registry Number.

1427043-08-0Relevant articles and documents

Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases i and II for treatment of myocardial reperfusion injury

Van Zandt, Michael C.,Whitehouse, Darren L.,Golebiowski, Adam,Ji, Min Koo,Zhang, Mingbao,Beckett, R. Paul,Jagdmann, G. Erik,Ryder, Todd R.,Sheeler, Ryan,Andreoli, Monica,Conway, Bruce,Mahboubi, Keyvan,D'Angelo, Gerard,Mitschler, Andre,Cousido-Siah, Alexandra,Ruiz, Francesc X.,Howard, Eduardo I.,Podjarny, Alberto D.,Schroeter, Hagen

, p. 2568 - 2580 (2013/05/21)

Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent α,α-disubstituted amino acid-based arginase inhibitors. The lead candidate, (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid, compound 9, inhibits human arginases I and II with IC50s of 223 and 509 nM, respectively, and is active in a recombinant cellular assay overexpressing human arginase I (CHO cells). It is 28% orally bioavailable and significantly reduces the infarct size in a rat model of myocardial ischemia/reperfusion injury. Herein, we report the design, synthesis, and structure-activity relationships (SAR) for this novel series of inhibitors along with pharmacokinetic and in vivo efficacy data for compound 9 and X-ray crystallography data for selected lead compounds cocrystallized with arginases I and II.

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