1427170-36-2Relevant academic research and scientific papers
Multienzyme One-Pot Cascade for the Stereoselective Hydroxyethyl Functionalization of Substituted Phenols
Payer, Stefan E.,Pollak, Hannah,Schmidbauer, Benjamin,Hamm, Florian,Juri?i?, Filip,Faber, Kurt,Glueck, Silvia M.
supporting information, p. 5139 - 5143 (2018/09/13)
The operability and substrate scope of a redesigned vinylphenol hydratase as a single biocatalyst or as part of multienzyme cascades using either substituted coumaric acids or phenols as stable, cheap, and readily available substrates are reported.
Asymmetric enzymatic hydration of hydroxystyrene derivatives
Wuensch, Christiane,Gross, Johannes,Steinkellner, Georg,Gruber, Karl,Glueck, Silvia M.,Faber, Kurt
supporting information, p. 2293 - 2297 (2013/04/10)
More than one activity: Owing to their hydratase activity, phenolic acid decarboxylases catalyze the regio- and stereoselective addition of H 2O across the C=C double bond of hydroxystyrene derivatives yielding (S)-4-(1-hydroxyethyl)phenols with up to 82 % conversion and 71 % ee. Based on structure analysis and molecular docking simulations, a catalytic mechanism for this novel enzymatic reaction is proposed. Copyright
