1427205-47-7Relevant articles and documents
Transannulation of 1-sulfonyl-1,2,3-triazoles with heterocumulenes
Chuprakov, Stepan,Kwok, Sen Wai,Fokin, Valery V.
, p. 4652 - 4655 (2013)
Readily available 1-mesyl-1,2,3-triazoles are efficiently converted into a variety of imidazolones and thiazoles by Rh(II)-catalyzed denitrogenative reactions with isocyanates and isothiocyanates, respectively. The proposed triazole-diazoimine equilibrium results in the formation of highly reactive azavinyl metal-carbenes, which react with heterocumulenes causing an apparent swap of 1,2,3-triazole core for another heterocycle.
Rhodium-Catalyzed Intermolecular C-H Functionalization as a Key Step in the Synthesis of Complex Stereodefined β-Arylpyrrolidines
Kubiak, Robert W.,Davies, Huw M. L.
supporting information, p. 3771 - 3775 (2018/07/25)
The synthesis of β-arylpyrrolidines via a catalytic enantioselective intermolecular allylic C(sp)3-H functionalization of trans-alkenes followed by immediate reduction, ozonolysis, and then in situ diversification of the resulting cyclic hemiaminal to furnish highly substituted, stereoenriched β-arylpyrrolidines is reported. This methodology utilizes 4-aryl-1-sulfonyl-1,2,3-triazoles as carbene precursors and the dirhodium tetracarboxylate catalyst Rh2(S-NTTL)4. A variety of β-arylpyrrolidines were prepared in good yields with high levels of diastereo- and enantioselectivity over four linear steps, requiring only a single purification procedure.
