1427208-12-5Relevant articles and documents
Neuroactive Steroid N-Methyl- d -aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity
La, Daniel S.,Salituro, Francesco G.,Martinez Botella, Gabriel,Griffin, Andrew M.,Bai, Zhu,Ackley, Michael A.,Dai, Jing,Doherty, James J.,Harrison, Boyd L.,Hoffmann, Ethan C.,Kazdoba, Tatiana M.,Lewis, Michael C.,Quirk, Michael C.,Robichaud, Albert J.
, p. 7526 - 7542 (2019)
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(S)-hydroxycholesterol (24(S)-HC), is a positive allosteric modulator (PAM) of NMDA receptors. Using 24(S)-HC as a chem