1427266-00-9

Basic information

• Product Name: 1,4-bis[6,9-dihydro-6-oxo-1-(4-methylphenyl)-9-phenyl-1H-purin-2-yl]piperazine
• CAS NO: 1427266-00-9
• Molecular Weight: 686.776
• Mol File: 1427266-00-9.mol

Chemical Properties

• CAS DataBase Reference: 1,4-bis[6,9-dihydro-6-oxo-1-(4-methylphenyl)-9-phenyl-1H-purin-2-yl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis[6,9-dihydro-6-oxo-1-(4-methylphenyl)-9-phenyl-1H-purin-2-yl]piperazine(1427266-00-9)
• EPA Substance Registry System: 1,4-bis[6,9-dihydro-6-oxo-1-(4-methylphenyl)-9-phenyl-1H-purin-2-yl]piperazine(1427266-00-9)

Safety Data

• Hazardous Substances Data: 1427266-00-9(Hazardous Substances Data)

Upstream product

• 622-58-2 p-Tolylisocyanate 
• 1132702-97-6 C₃₀H₂₆N₃O₂P 

Relevant articles and documents

Sequential three-component synthesis of 1,4-bis[6,9-dihydro-6-oxo-9- Phenyl-1H-purin-2-yl]piperazines

A simple one-pot efficient method for the synthesis of 1,4-bis[6,9-dihydro- 6-oxo-9-phenyl-1H-purin-2-yl]piperazines by a domino three-component process involves an aza-Wittig reaction/heterocyclisation in the presence of sodium ethoxide as catalyst. Ethyl 1-phenyl-5-[(triphenylphosphoranylidene)amino]-1H- imidazole-4-carboxylate reacted with aromatic isocyanate to give carbodiimide intermediates, followed by addition of piperazines to give the corresponding guanidine intermediates. The guanidine intermediates were cyclised in the presence of a catalytic amount of sodium ethoxide to give 1,4-bis(6,9-dihydro-6- oxo-9-phenyl-1H-purin-2-yl)piperazine derivatives in good yields.