1427271-99-5 Usage
Uses
Used in Pharmaceutical Industry:
(R)-tert-butyl(1-(7-cyano-1-(3-hydroxypropyl)indolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate is used as a potential pharmaceutical compound for its diverse functional groups that may contribute to its biological activity and interactions with biological targets.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-tert-butyl(1-(7-cyano-1-(3-hydroxypropyl)indolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate could be utilized as a precursor or active ingredient in the development of new pesticides or herbicides, leveraging its structural complexity and chirality.
Used in Materials Science:
(R)-tert-butyl(1-(7-cyano-1-(3-hydroxypropyl)indolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate may also find applications in materials science, where its unique structural features could be exploited to create novel materials with specific properties, such as improved stability or reactivity in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1427271-99-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,2,7 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1427271-99:
(9*1)+(8*4)+(7*2)+(6*7)+(5*2)+(4*7)+(3*1)+(2*9)+(1*9)=165
165 % 10 = 5
So 1427271-99-5 is a valid CAS Registry Number.
1427271-99-5Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF INDOLINE COMPOUND
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Page/Page column 16-17, (2018/06/22)
The present invention relates to an improved process for the preparation of Silodosin (I) which is useful in the treatment of Benign Prostate Hyperplasia (BPH) and related disorders. The present invention also relates to the purification process resulting in substantially pure Silodosin.
Enantioselective synthesis of (-)-(R) Silodosin by ultrasound-assisted diastereomeric crystallization
Barve, Indrajeet J.,Chen, Li-Hsun,Wei, Patrick C.P.,Hung, Jui-Te,Sun, Chung-Ming
, p. 2834 - 2843 (2013/04/10)
Enantioselective synthesis of clinically approved drug - Silodosin for the treatment of benign prostatic hyperplasia from the commercially available compounds 1-acetyl-5-(2-aminopropyl) indoline-7-carbonitrile A and 2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl methanesulfonate C is explored. Key step in the synthesis is chiral resolution of intermediate 1, which was achieved by a simple diastereomeric crystallization using (S)-(+)-mandelic acid assisted by ultrasonication. The present synthetic strategy has lesser number of steps and is vastly improved the overall yield in this short route towards target compound - Silodosin.
