142728-99-2Relevant academic research and scientific papers
IMPORTANCE OF THE 2-HYDROXY GROUP FOR THE REACTIONS OF AN ACETATE OF A NATURALLY OCCURRING PROHIBITIN, 4-ACETOXY-2-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE, WITH NUCLEOPHILES
Ishizaki, Takayoshi,Hashimoto, Yuichi,Shudo, Koichi
, p. 651 - 656 (2007/10/02)
A prohibitin, 2,4-dihydroxy-2H-1,4-benzoxazin-3-(4H)-one, reacted readily with nucleophiles after 4-O-acetylation.The 2-hydroxy group is mandatory for the reactions.The plausible interpretation for the enhancing effect of the 2-hydroxy group on the benzoxazinone system's reactivity involves an acetal ring-opening and reclosure mechanism.
