1427310-66-4

Basic information

• Product Name: C₂₉H₃₆FN₇O₂
• Synonyms: C₂₉H₃₆FN₇O₂
• CAS NO: 1427310-66-4
• Molecular Weight: 533.649
• Mol File: 1427310-66-4.mol

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₆FN₇O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₆FN₇O₂(1427310-66-4)
• EPA Substance Registry System: C₂₉H₃₆FN₇O₂(1427310-66-4)

Safety Data

• Hazardous Substances Data: 1427310-66-4(Hazardous Substances Data)

Upstream product

• 114873-11-9 boc-L-3-(3-fluorophenyl)alanine 
• 1227361-00-3 C₂₄H₂₄FN₅O₃ 
• 142-25-6 N,N',N'-trimethylenediamine 
• 16313-66-9 5-bromoanthranilamide 
• 1227360-99-7 C₂₁H₂₃BrFN₃O₄ 
• 1227361-00-3 C₂₄H₂₄FN₅O₃ 

Downstream Products

• 1227361-01-4 (R)-N₁-(2-(1-amino-2-(3-fluorophenyl)ethyl)-6-(1H-pyrazol-4-yl)quinazolin-4-yl)-N,N,N'-trimethylethane-1,2-diamine 

Relevant articles and documents

Amino acid derived quinazolines as Rock/PKA inhibitors

SAR and lead optimization studies for Rock inhibitors based on amino acid-derived quinazolines are described. Studies demonstrated that these amino acid derived quinazolinones were mainly pan-Rock (I & II) inhibitors. While selectivity against other kinas

QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS

The invention is directed to quinazoline compounds that can inhibit the bioactivity of one or more kinase enzymes, including a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Fit kinase, an Aurora kinase, or a Src kinase, or any combination thereof; to methods of use of those compounds; and to methods of preparation of those compounds. The inventive compounds can be used in the treatment of malconditions including cardiovascular disease, neurogenic pain, hypertension, atherosclerosis, angina, stroke, arterial obstruction, peripheral arterial disease, erectile dysfunction, acute and chronic pain, dementia, Alzheimer's disease, Parkinson's disease, neuronal degeneration, asthma, amyotrophic lateral sclerosis, spinal cord injury, rheumatoid arthritis, osteoarthritis, osteoporosis, psoriasis, cerebral vasospasm, open angle glaucoma, multiple sclerosis, pulmonary hypertension, acute respiratory distress syndrome, inflammation, diabetes, urinary organ diseases and benign prostatic hypertrophy (BPH), metastasis, cancer, glaucoma, ocular hypertension, retinopathy, autoimmune disease, viral infection, or myocardial pathology.