1427322-99-3Relevant academic research and scientific papers
Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones
Meyer, Christina,Neue, Benedikt,Schepmann, Dirk,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Würthwein, Ernst-Ulrich,Itami, Kenichiro,Wünsch, Bernhard
, p. 1844 - 1856 (2013)
The direct C-H-bond arylation of the complex spirocyclic lactones 13, 14, and 18 allows the introduction of diverse aryl moieties in the last step of the synthesis. A selective α-arylation of the thiophene moiety was performed with the catalytic system Pd
