1427330-74-2

Basic information

• Product Name: 3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one
• Synonyms: 3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS NO: 1427330-74-2
• Molecular Weight: 385.382
• Mol File: 1427330-74-2.mol

Chemical Properties

• CAS DataBase Reference: 3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one(1427330-74-2)
• EPA Substance Registry System: 3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one(1427330-74-2)

Safety Data

• Hazardous Substances Data: 1427330-74-2(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 401588-96-3 2-amino-N-(1H-benzo[d]imidazol-2-yl)benzamide 
• 934-32-7 1H-benzimidazol-2-amine 
• 118-48-9 isatoic anhydride 

Relevant articles and documents

Facile, catalyst-free, microwave-assisted access toward the synthesis of 2-aryl/alkyl-3-(1H-benzo[d]imidazol-2-yl)-2, 3-dihydroquinazolin-4(1H)-ones

An efficient, catalyst-free, microwave-assisted approach has been developed for the synthesis of 2-aryl/alkyl-3-(1H-benzo[d]imidazol-2-yl)-2,3-dihydroquinazolin-4(1H)-one derivatives by condensing 2-aminobenzamides with various aliphatic, aromatic, and heterocyclic aldehydes. This catalyst-free approach exhibited good functional group compatibility and produced the desired products in good to excellent yields in just 10–20 min. This approach can be seen as a better alternative of the metal-catalyzed protocols used for the synthesis of this class of compounds. The formation of desired compound has also been confirmed by X-ray analysis.

One-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones by Fe3O4@SiO2-imid-PMAn nano-catalyst under ultrasonic irradiation and reflux conditions

Abstract: Fe3O4@SiO2-imid-PMAn efficiently catalyzes the condensation reaction of isatoic anhydride, aldehydes, and primary amines or ammonium salts to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives under ultrasonic irradiation or reflux conditions. This method gives notable advantages such as operational simplicity, excellent yields, short reaction times, and absence of any tedious workup or purification. In addition, the excellent catalytic performance and the easy preparation, thermal stability, and separation of the catalyst make it a good heterogeneous system and a useful alternative to other heterogeneous catalysts. Also, the aforementioned nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least six times without noticeable deterioration in catalytic activity and reaction yield. Graphical abstract: [Figure not available: see fulltext.]

New applications of phosphoric acid supported on alumina (H 3PO4-Al2O3) as a reusable heterogeneous catalyst for preparation of 2,3-dihydroquinazoline-4(1H)-ones, 2H-indazolo[2,1-b]phthalazinetriones, and benzo[4,5]imidazo[1,2-a]pyrimidines

An eco-friendly procedure for synthesis of 2,3-dihydroquinazoline-4(1H)- one, 2H-indazolo[2,1-b]phthalazinetrione, and benzo[4,5]imidazo[1,2-a]pyrimidine derivatives by three-component reaction, with phosphoric acid supported on alumina as catalyst, is described. Noticeable features of the method are that it is solvent-free, work-up is easy, yields are excellent, and the catalyst is reusable.