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3-bromo-6-fluoro-2-methyl-benzoic acid is an organic compound characterized by its unique molecular structure, which features a benzoic acid backbone with a bromine atom at the 3rd position, a fluorine atom at the 6th position, and a methyl group at the 2nd position. 3-bromo-6-fluoro-2-methyl-benzoic acid is known for its potential applications in the pharmaceutical and chemical industries due to its versatile chemical properties.

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  • 1427373-55-4 Structure
  • Basic information

    1. Product Name: 3-Bromo-6-fluoro-2-methyl-benzoic acid
    2. Synonyms: 3-Bromo-6-fluoro-2-methyl-benzoic acid
    3. CAS NO:1427373-55-4
    4. Molecular Formula: C8H6BrFO2
    5. Molecular Weight: 233.0344432
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1427373-55-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 307.2±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.680±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 2.57±0.31(Predicted)
    10. CAS DataBase Reference: 3-Bromo-6-fluoro-2-methyl-benzoic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-Bromo-6-fluoro-2-methyl-benzoic acid(1427373-55-4)
    12. EPA Substance Registry System: 3-Bromo-6-fluoro-2-methyl-benzoic acid(1427373-55-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1427373-55-4(Hazardous Substances Data)

1427373-55-4 Usage

Uses

Used in Pharmaceutical Industry:
3-bromo-6-fluoro-2-methyl-benzoic acid is used as a reagent for the preparation of aryl and heteroaryl fused lactams, which are known for their antitumor properties. These fused lactams are valuable in the development of new cancer treatments, as they can target specific cancer cells and inhibit their growth.
The compound's unique structure allows for the creation of various derivatives with potential therapeutic applications. Its use in the synthesis of antitumor agents highlights its importance in the ongoing research and development of novel cancer therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 1427373-55-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,3,7 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1427373-55:
(9*1)+(8*4)+(7*2)+(6*7)+(5*3)+(4*7)+(3*3)+(2*5)+(1*5)=164
164 % 10 = 4
So 1427373-55-4 is a valid CAS Registry Number.

1427373-55-4Relevant articles and documents

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

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Page/Page column 270, (2021/01/29)

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

TRICYCLIC AKR1C3 DEPENDENT KARS INHIBITORS

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Page/Page column 76, (2021/01/29)

The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

IRE1 SMALL MOLECULE INHIBITORS

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Paragraph 00267, (2019/01/04)

Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

ARYL AND HETEROARYL FUSED LACTAMS

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Paragraph 0816; 0817, (2014/07/08)

This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

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Page/Page column 99; 100, (2014/03/25)

Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to pharmaceutical compositions containing these inhibitors and to their use, alone or in combination with other HBV inhibitors, in HBV therapy.

SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

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Page/Page column 99-100, (2014/03/25)

Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

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Page/Page column 143, (2013/03/28)

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.

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