142738-94-1

Basic information

• Product Name: 3-(TRIFLUOROMETHOXY)ANISOLE
• Synonyms: 1-METHOXY-3-(TRIFLUOROMETHOXY)BENZENE;3-(TRIFLUOROMETHOXY)ANISOLE
• CAS NO: 142738-94-1
• Molecular Formula: C₈H₇F₃O₂
• Molecular Weight: 192.14
• Mol File: 142738-94-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 162℃
• Flash Point: 58℃
• Appearance: /
• Density: 1.249
• Vapor Pressure: 2.82mmHg at 25°C
• Refractive Index: 1.434
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 3-(TRIFLUOROMETHOXY)ANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TRIFLUOROMETHOXY)ANISOLE(142738-94-1)
• EPA Substance Registry System: 3-(TRIFLUOROMETHOXY)ANISOLE(142738-94-1)

Safety Data

• Hazard Codes: F,Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1993
• HazardClass: IRRITANT, FLAMMABLE
• PackingGroup: III
• Hazardous Substances Data: 142738-94-1(Hazardous Substances Data)

Usage

General Description

3-(TRIFLUOROMETHOXY)ANISOLE, also known as 1,2-Anisole, 3-(trifluoromethoxy)-, is a chemical compound with the molecular formula C8H7F3O2. It is a colorless liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The presence of the trifluoromethoxy group makes this compound useful for applications in the field of medicinal chemistry, where the introduction of fluorine atoms can enhance the bioavailability and metabolic stability of drug molecules. Additionally, this compound can also be used as a solvent in organic reactions and as a reagent in organic synthesis. Its unique properties and versatility make it a valuable component in the field of organic and medicinal chemistry.

InChI:InChI=1/C8H7F3O2/c1-12-6-3-2-4-7(5-6)13-8(9,10)11/h2-5H,1H3

Upstream product

• 512-56-1 trimethyl phosphite 
• 827-99-6 3-(trifluoromethoxy)phenol 
• 1006904-72-8 silver(I) trifluoromethoxide 
• 217813-03-1 3-methoxy-2-(trimethylsilyl)phenyl-trifluoromethanesulfonate 
• 74-88-4 methyl iodide 
• 536-90-3 m-Anisidine 

Downstream Products

• 142739-14-8 2-Methoxy-4-trifluoromethoxy-benzenesulfonic acid 
• 142739-13-7 4-Methoxy-2-trifluoromethoxy-benzenesulfonic acid 
• 905077-14-7 potassium 4-methoxy-2-(trifluoromethoxy)benzenesulfonate 
• 905077-18-1 potassium 2-methoxy-4-(trifluoromethoxy)benzenesulfonate 

Relevant articles and documents

A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination

A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.

Method for trifluoro methoxylation of arylamine

The invention provides a method for synthesizing an aryltrifluoromethoxy compound from an arylamine compound. The method comprises the steps of: performing a diazotization reaction on arylamine, and performing a one-pot reaction between the obtained aryl diazonium salt and trifluoromethoxy silver in an acetonitrile solvent so as to obtain the corresponding aryltrifluoromethoxy product. The obtained product has a high yield, and the process is simple.

1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle

It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.