1427548-48-8

Basic information

• Product Name: C₃₃H₃₂ClN₅O₂S₂
• Synonyms: C₃₃H₃₂ClN₅O₂S₂
• CAS NO: 1427548-48-8
• Molecular Weight: 630.234
• Mol File: 1427548-48-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₂ClN₅O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₂ClN₅O₂S₂(1427548-48-8)
• EPA Substance Registry System: C₃₃H₃₂ClN₅O₂S₂(1427548-48-8)

Safety Data

• Hazardous Substances Data: 1427548-48-8(Hazardous Substances Data)

Upstream product

• 155817-87-1 2-methyl-10-(4-methyl-piperazinyl)-4-prop-2-ynyl-4H-3-thia-4,9-diaza-benzo[f]azulene 
• 1351706-37-0 N-(2-iodo-4-chlorophenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Novel N-indolylmethyl substituted olanzapine derivatives: Their design, synthesis and evaluation as PDE4B inhibitors

A new strategy for converting antipsychotic drug olanzapine into PDE4 inhibitors is described via the design and Pd/C mediated synthesis of novel N-indolylmethyl olanzapine derivatives. One compound showed good inhibition (IC50 1.1 μM) and >10 fold selectivity towards PDE4B over D that was supported by docking studies. This compound also showed significant inhibition of TNF-α and no major toxicities in cell lines and a zebrafish embryo model except the teratogenic effects to be re-assessed in rodents. The Royal Society of Chemistry 2013.