1427578-85-5

Basic information

• Product Name: 5-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,3-phenylene diacetate
• CAS NO: 1427578-85-5
• Molecular Weight: 338.32
• Mol File: 1427578-85-5.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,3-phenylene diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,3-phenylene diacetate(1427578-85-5)
• EPA Substance Registry System: 5-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,3-phenylene diacetate(1427578-85-5)

Safety Data

• Hazardous Substances Data: 1427578-85-5(Hazardous Substances Data)

Upstream product

• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 1427578-65-1 2-(3,5-dihydroxyphenyl)quinazolin-4(3H)-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 1427578-92-4 C₂₁H₁₆N₂O₅ 
• 1427579-83-6 C₃₉H₃₃N₅O₁₁ 
• 1427579-46-1 C₃₅H₂₉N₇O₆ 
• 1427579-44-9 C₃₇H₃₁N₇O₇ 
• 1427579-43-8 C₃₅H₂₉N₇O₅ 
• 1427579-23-4 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate 
• 1427579-17-6 3-(4-azidobutyl)-2-(3,5-dihydroxyphenyl)quinazolin-4(3H)-one 
• 1427578-97-9 2-(3,5-dihydroxyphenyl)-3-(prop-2-yn-1-yl)quinazolin-4(3H)-one 

Relevant articles and documents

Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site

To discover promising sulfated allosteric modulators (SAMs) of glycosaminoglycan-binding proteins (GBPs), such as human factor XIa (FXIa), we screened a library of 26 synthetic, sulfated quinazolin-4(3H)-ones (QAOs) resulting in the identification of six molecules that reduced the V max of substrate hydrolysis without influencing the KM. Mutagenesis of residues of the heparin-binding site (HBS) of FXIa introduced a nearly 5-fold loss in inhibition potency supporting recognition of an allosteric site. Fluorescence studies showed a sigmoidal binding profile indicating highly cooperative binding. Competition with a positively charged, heparin-binding polymer did not fully nullify inhibition suggesting importance of hydrophobic forces to binding. This discovery suggests the operation of a dual-element recognition process, which relies on an initial Coulombic attraction of anionic SAMs to the cationic HBS of FXIa that forms a locked complex through tight interaction with an adjacent hydrophobic patch. The dual-element strategy may be widely applicable for discovering SAMs of other GBPs.