142758-98-3Relevant academic research and scientific papers
3-O-Alkyl-2,3-dehydrosilibinins: Two synthetic approaches and in vitro effects toward prostate cancer cells
Zhang, Sheng,Vue, Bao,Huang, Michael,Zhang, Xiaojie,Lee, Timmy,Chen, Guanglin,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong
, p. 3226 - 3231 (2016)
Eight 3-O-alkyl-2,3-dehydrosilibinins have been synthesized from commercially available silibinin through two synthetic approaches. A one-pot reaction, starting with aerobic oxidation of silibinin followed by direct alkylation of the phenolic hydroxyl gro
The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein
Maitrejean, Mathias,Comte, Gilles,Barron, Denis,El Kirat, Karim,Conseil, Gwenaelle,Di Pietro, Attilio
, p. 157 - 160 (2000)
A new series of potential flavonoidic modulators of P-glycoprotein activity has been prepared. The flavanolignan silybin was first oxidised to dehydrosilybin and then C-alkylated with either prenyl or geranyl bromide. The resulting isoprenoid dehydrosilyb
PREPARATION METHOD OF CHROMENONE DERIVATIVES USING RADIATION
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Paragraph 0054; 0055, (2013/06/27)
A preparation method of chromenone derivatives using radiation is provided. The preparation method exposes commercially-available silybin in reaction solvent to radiation, to thereby concurrently obtain both dehydrosilybin and apigenin compounds, which are chromenone compounds, in a simple reaction step and with high yield. Because the compounds are prepared at economic cost, the preparation method can be advantageously used particularly for the purpose of mass production. Further, in consideration of good cancer cell viability suppression effect thereof, dehydrosilybin and apigenin prepared according to the preparation method can be advantageously used as a pharmaceutical composition for prevention and treatment of cancer.
Microwave-assisted oxidation of silibinin: A simple and preparative method for the synthesis of improved radical scavengers
Di Fabio, Giovanni,Romanucci, Valeria,De Nisco, Mauro,Pedatella, Silvana,Di Marino, Cinzia,Zarrelli, Armando
, p. 6279 - 6282 (2013/10/22)
A new and preparative oxidation of silibinin has been developed to give access to two different silibinin derivatives known for their enhanced antioxidant properties. Conventional heating methods were compared with results obtained from microwave (MW) heating. The base-catalysed oxidation of silibinin under MW heating is a very efficient method for the preparation of 2,3-dehydrosilybin and a related silybin rearrangement product. This latter compound shows enhanced radical scavenging properties. Optimised conditions were used to prepare 2,3-dehydrosilybins A and B from optically pure silybins A and B. An efficient, preparative purification method was also developed to enable isolation of different products in high purity.
New C-23 modified of silybin and 2,3-dehydrosilybin: Synthesis and preliminary evaluation of antioxidant properties
Zarrelli, Armando,Sgambato, Alessandro,Petito, Valentina,De Napoli, Lorenzo,Previtera, Lucio,Di Fabio, Giovanni
supporting information; experimental part, p. 4389 - 4392 (2011/09/15)
Silybin is the major flavonolignan of silymarin and it displays a plethora of biological effects, generally ascribed to its antioxidant properties. Herein we shall describe an efficient synthetic strategy to obtain a variety of new and more water-soluble
Oxidised derivatives of silybin and their antiradical and antioxidant activity
Ga?ák, Radek,Svobodová, Alena,Psotová, Jitka,Sedmera, Petr,P?ikrylová, Věra,Walterová, Daniela,K?en, Vladimír
, p. 5677 - 5687 (2007/10/03)
Carboxylic acids derived from silybin (1) and 2,3-dehydrosilybin (2) with improved water solubility were prepared by selective oxidation of parent compounds and a new inexpensive method for preparation of 2,3-dehydrosilybin from silybin was developed and
