142764-18-9

Basic information

• Product Name: 1,2,5-Oxadiazole, 3-[(4-methoxyphenyl)sulfonyl]-4-methyl-, 5-oxide
• CAS NO: 142764-18-9
• Molecular Formula: C10H10N2O5S
• Molecular Weight: 270.266
• Mol File: 142764-18-9.mol

Chemical Properties

• CAS DataBase Reference: 1,2,5-Oxadiazole, 3-[(4-methoxyphenyl)sulfonyl]-4-methyl-, 5-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Oxadiazole, 3-[(4-methoxyphenyl)sulfonyl]-4-methyl-, 5-oxide(142764-18-9)
• EPA Substance Registry System: 1,2,5-Oxadiazole, 3-[(4-methoxyphenyl)sulfonyl]-4-methyl-, 5-oxide(142764-18-9)

Safety Data

• Hazardous Substances Data: 142764-18-9(Hazardous Substances Data)

Upstream product

• 142764-09-8 4-(4-Methoxy-phenylsulfanyl)-3-methyl-furazan 2-oxide 
• 696-63-9 4-Methoxybenzenethiol 
• 142764-06-5 N-Hydroxy-2-[(E)-hydroxyimino]-thiopropionimidic acid 4-methoxy-phenyl ester 

Relevant articles and documents

Pharmacochemistry of the furoxan ring: Recent developments

In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.

4-Methyl-3-(arylsulfonyl)furoxans: A New Class of Potent Inhibitors of Platelet Aggregation

A series of 4-methyl-3-(arylthio)furoxans were synthesized by oxidation of 1-(arylthio)-2-methylglyoxymes with dinitrogen tetroxide.Reduction with trimethyl phosphite of the furoxan derivatives afforded the corresponding furazans, while oxidation with an