1427669-38-2Relevant academic research and scientific papers
Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway
Qi, Jianguo,Huang, Jing,Zhou, Xiaomin,Luo, Wen,Xie, Jiaxin,Niu, Linqiang,Yan, Zhijie,Luo, Yang,Men, Yuhui,Chen, Yanan,Zhang, Yahong,Wang, Jianhong
, p. 617 - 627 (2019/01/18)
A series of novel quinoxaline derivatives were synthesized and evaluated for their antiproliferative activity in three human cancer cell lines. Compound 12 exhibited the most potent antiproliferative activity with IC50 in the range of 0.19–0.51
Design, synthesis and biological studies of novel tubulin inhibitors
Sun, Yanjun,Pandit, Bulbul,Chettiar, Somsundaram N.,Etter, Jonathan P.,Lewis, Andrew,Johnsamuel, Jayasekar,Li, Pui-Kai
, p. 4465 - 4468 (2013/07/26)
A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, were synthesized and evaluated. The most potent compound in this series, compound 3, which structurally resembles the potent a
Method for treating neoplasia by exposure to N,N′-substituted benzimidazol-2-ones
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, (2008/06/13)
A method for inhibiting neoplastic cells and related conditions by exposing them to N,N′-substituted benzimidazol-2-ones.
