142777-65-9Relevant academic research and scientific papers
BIPHENYL DERIVATIVES
-
Page/Page column 18-19, (2008/06/13)
Biphenyl derivatives represented by the following formula (1): wherein R1 represents a C5-7 alkyl group, R2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R3 represents a te
Inhibitors of acyl-CoA:Cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate
Picard, Joseph A.,O'Brien, Patrick M.,Sliskovic, Drago R.,Anderson, Maureen K.,Bousley, Richard F.,Hamelehle, Katherine L.,Krause, Brian R.,Stanfield, Richard L.
, p. 1243 - 1252 (2007/10/03)
Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro,
Oxysulfonyl urea ACAT inhibitors
-
, (2008/06/13)
Novel compounds of the formula STR1 wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein each of R1 and R2 is hydrogen, an aralkyl group, a straight or branched hydrocarbon group having from 1 to 20 carbon atoms and may be saturated or unsaturated, an alkyl group of from 1 to 6 carbon atoms wherein the terminal carbon is substituted, the group --(CH2)p)--Q wherein p is zero to three and Q is a 5- or 6-membered monocyclic or fused bicyclic heterocycle, phenyl or NR1 R2 taken together form a monocyclic heterocyclic ring, and R3 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, --(CH2)p --Q wherein p and Q are as defined above, an aralkyl group or a straight or branched hydrocarbon group having from 1 to 20 carbon atoms and being straight or branched.
Aminosulfonyl urea ACAT inhibitors
-
, (2008/06/13)
The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels, pharmaceutical compositions and methods of using the ACAT inhi
