142780-69-6

Basic information

• Product Name: 7-chloro-5-(3,3-<(2)H>cyclohex-1-en-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
• CAS NO: 142780-69-6
• Molecular Weight: 290.761
• Mol File: 142780-69-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-chloro-5-(3,3-<(2)H>cyclohex-1-en-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-5-(3,3-<(2)H>cyclohex-1-en-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one(142780-69-6)
• EPA Substance Registry System: 7-chloro-5-(3,3-<(2)H>cyclohex-1-en-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one(142780-69-6)

Safety Data

• Hazardous Substances Data: 142780-69-6(Hazardous Substances Data)

Upstream product

• 10379-14-3 tetrazepam 

Relevant articles and documents

Autoxidation of tetrazepam in tablets: Prediction of degradation impurities from the oxidative behavior in solution

The major route of degradation of tetrazepam (1) is oxidation to 7-chloro- 5-(3-keto-cyclohexen-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one (3) via the stable 7-chloro-5-(3-hydroperoxy-cyclohexen-1-yl)-1,3-dihydro-1- methyl-2H-1,4 benzodiazepin-2-one (2). Minor degradation products are 7- chloro-5-(1,2-epoxycyclohexan-1-yl)-1,3-dihydro-1-methyl-2H-1,4- benzodiazepin-2-one (5) and 7-chloro-1,3-dihydro-1-methyl-2H-1,4- benzodiazepin-2,5-dione (4), resulting from cleavage of the C-C bond between the cyclohexene ring and the benzodiazepine ring. After 48 h, AIBN (2,2'- azobis[2-methyl-propanenitrile]) in acetonitrile at 40 °C produced qualitatively the same impurities as those observed in the stability study of tablets of 1. Other stress tests (thermal stress at 80 °C, heavy metal oxidation, hydrogen peroxide, acid-catalyzed oxidation) caused qualitatively different profiles of degradation.