1427804-06-5Relevant academic research and scientific papers
Efficient [5+1] synthesis of 4-quinolones by domino amination and conjugate addition reactions of 1-(2-fluorophenyl)prop-2-yn-1-ones with amines
Iaroshenko, Viktoro.,Mkrtchyan, Satenik,Villinger, Alexander
, p. 205 - 218 (2013/02/25)
A catalyst-free synthetic approach is described for the synthesis of 4-quinolone derivatives through a tandem amination/conjugated Michael addition sequence of 1-(2-fluorophenyl)prop-2-yn-1-one derivatives. The [5+1]-cyclization proceeds efficiently at a high temperature under an inert atmosphere with lithium carbonate as a base, and it provides a practical route to a diverse range of 4-quinolones. The mechanism was studied in details and several of the intermediates were isolated. Georg Thieme Verlag Stuttgart New York.
