142784-71-2

Upstream product

• 116585-12-7 2-((tert-butyldimethylsilyl)oxy)benzaldehyde 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 38865-40-6 1-(2'-hydroxyphenyl)prop-2-en-1-ol 
• 89-95-2 2-methyl-benzyl alcohol 
• 274927-62-7 (1'R,S)-1-(2-acetoxyphenyl)-2-propene-1-acetate 
• 1481-84-1 2-hydroxy-α-ethylbenzylalcohol 
• 108-24-7 acetic anhydride 

Downstream Products

• 166282-07-1 3-(1'-(2-Acetoxyphenyl)propyl)-4-hydroxycoumarin 
• 33176-18-0 1-(o-Hydroxyphenyl)propyl acetate 

Relevant academic research and scientific papers

Structure-activity relationships of 1′S-1′-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages

1′S-1′-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC50 value of 2.3 μM. To clarify the structure-activity relationship of 1′S-1′- acetoxychavicol acetate, various natural and synthetic phenylpropanoids and synthetic phenylbutanoids were examined, and the following structural requirements were clarified. (1) The para or ortho substitution of the acetoxyl and 1-acetoxypropenyl groups at the benzene ring was essential. (2) The S configuration of the 1′-acetoxyl group was preferable. (3) The presence of the 3-methoxyl group and disappearance of the 2′-3′ double bond by hydrogenation reduced the activity. (4) The substitution of acetyl groups with propionyl or methyl groups reduced the activity. (5) Lengthening of the carbon chain between the 1′- and 2′-positions reduced the activity.

Regio- and Chemo-selective Properties of Lipase from Candida cylindracea

Lipase from Candida cylindracea allows discrimination between the two connectively non-equivalent hydroxy groups in primary diols or their esters via acylation-hydrolysis, with high regioselectivity.The same technique is used to distinguish between hydroxy groups of different nature in phenolic compounds.