1428-95-1 Usage
Description
5-(N,N-HEXAMETHYLENE)-AMILORIDE, also known as HMA, is a derivative of amiloride with a wide range of biological activities. It is characterized as an allosteric antagonist of adenosine A2A receptors and exhibits potent inhibitory effects on various ion channels and cancer cells. HMA is a member of the pyrazine class, where the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.
Uses
Used in Pharmaceutical Industry:
5-(N,N-HEXAMETHYLENE)-AMILORIDE is used as an allosteric antagonist for adenosine A2A receptors, playing a crucial role in the development of potential therapeutic agents targeting these receptors.
Used in Antiviral Applications:
HMA is used as an inhibitor of cation-selective ion channels formed by HIV-1 viral protein Vpu and hepatitis C virus (HCV) protein p7, making it a potential candidate for the development of antiviral drugs.
Used in Cancer Therapy:
5-(N,N-HEXAMETHYLENE)-AMILORIDE is used as a necrosis inducer and viability reducer in various breast cancer cell lines, including MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL, without affecting cardiomyocytes or uterine, pulmonary, and renal epithelial cells. This selective toxicity makes HMA a promising agent for cancer treatment.
Used in Cardiovascular Protection:
HMA is used as a protective agent against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls, highlighting its potential application in the treatment of cardiovascular diseases.
Biochem/physiol Actions
Inhibitor of Na+/H+ antiport.
Check Digit Verification of cas no
The CAS Registry Mumber 1428-95-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1428-95:
(6*1)+(5*4)+(4*2)+(3*8)+(2*9)+(1*5)=81
81 % 10 = 1
So 1428-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)