1428098-38-7

Upstream product

• 106-95-6 allyl bromide 
• 168828-81-7 benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1428098-61-6 benzyl 3-fluoro-4-morpholinophenyl(4,4,5,5,6,6,7,7,7-nonafluoro-2-iodoheptyl)carbamate 
• 1428098-83-2 3-(3-fluoro-4-morpholinophenyl)-5-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)oxazolidin-2-one 
• 1428098-72-9 5-(3-chloro-2,2,3,3-tetrafluoropropyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one 
• 1428098-51-4 benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate 
• 224323-50-6 linezolid 
• 620-05-3 iodomethylbenzene 

Relevant academic research and scientific papers

The Synthesis of Functionalized 3-Aryl- And 3-Heteroaryloxazolidin-2-ones and Tetrahydro-3-aryl-1,3-oxazin-2-ones via the Iodocyclocarbamation Reaction: Access to Privileged Chemical Structures and Scope and Limitations of the Method

3-Aryl- and 3-heteroaryloxazolidin-2-ones, by virtue of the diverse pharmacologic activities exhibited by them after subtle changes to their appended substituents, are becoming increasingly important and should be considered privileged chemical structures

Microwave-assisted expeditious synthesis of 5-fluoroalkyl-3-(aryl/alkyl)- oxazolidin-2-ones

An efficient and convenient protocol for synthesis of 5-fluoroalkyl-3- (aryl/alkyl)-oxazolidin-2-ones is described. The reaction of allyl (aryl/alkyl) carbamates with fluoroalkyl iodide initiated by sodium dithionite in aqueous acetonitrile resulted in adducts that undergoes a cyclization assisted by microwave irradiation to form 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones with high yields. It was also found that the products can be more efficiently formed via an AIBN-initiated one-pot addition-cyclization sequence from benzyl allyl(aryl/alkyl) carbamates and fluoroalkyl iodide.