1428156-98-2Relevant academic research and scientific papers
Directed carbonylative (3+1+2) cycloadditions of amino-substituted cyclopropanes and alkynes: Reaction development and increased efficiencies using a cationic rhodium system
Shaw, Megan H.,Whittingham, William G.,Bower, John F.
, p. 2731 - 2741 (2016/05/19)
Urea-directed carbonylative insertion of Rh(I)-catalysts into one of the two proximal C-C bonds of aminocyclopropanes generates rhodacyclopentanone intermediates. These are trapped by N-tethered alkynes to provide a (3+1+2) cycloaddition protocol that acc
Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: Rhodium-catalyzed multicomponent synthesis of N-heterobicyclic enones
Shaw, Megan H.,Melikhova, Ekaterina Y.,Kloer, Daniel P.,Whittingham, William G.,Bower, John F.
, p. 4992 - 4995 (2013/05/22)
Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.
