1428185-71-0

Basic information

• Product Name: (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine
• Synonyms: (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine;(αR)-α-Methyl-N-[3-[4-(trifluoroMethyl)phenyl]propyl]-1-naphthaleneMethan aMine;(alphaR)-alpha-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine;Cinacalcet Impurity 1;N-[(1R)-1-naphthalen-1-ylethyl]-3-[4-(trifluoromethyl)phenyl]propan-1-amine
• CAS NO: 1428185-71-0
• Molecular Formula: C22H22F3N
• Molecular Weight: 357.4119896
• Product Categories: Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1428185-71-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 448.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
• PKA: 9.13±0.29(Predicted)
• CAS DataBase Reference: (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine(1428185-71-0)
• EPA Substance Registry System: (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine(1428185-71-0)

Safety Data

• Hazardous Substances Data: 1428185-71-0(Hazardous Substances Data)

Usage

Description

(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)propan-1-amine is a complex organic compound characterized by its unique molecular structure. It features a naphthalene ring attached to an ethyl group, which is connected to a propan-1-amine group. Additionally, a 4-(trifluoromethyl)phenyl group is present, contributing to the compound's properties. This molecule is known for its specific stereochemistry, with the R-configuration at the nitrogen atom, which is crucial for its potential applications and interactions.

Uses

Used in Pharmaceutical Industry:
(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)propan-1-amine is used as an impurity in the drug Cinacalcet (C441800). This drug functions as a calcimimetic, which means it mimics the action of calcium in regulating the parathyroid hormone levels. Specifically, it is utilized to treat secondary hyperparathyroidism, a condition characterized by elevated parathyroid hormone levels. The presence of this compound as an impurity in Cinacalcet highlights its relevance in the pharmaceutical sector, where it may influence the drug's efficacy, safety, or pharmacokinetics.