1428188-07-1

Basic information

• Product Name: 2-(3-(oct-1-ynyl)phenyl)-4-phenylpyrimidine
• Synonyms: 2-(3-(oct-1-ynyl)phenyl)-4-phenylpyrimidine
• CAS NO: 1428188-07-1
• Molecular Weight: 340.468
• Mol File: 1428188-07-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-(oct-1-ynyl)phenyl)-4-phenylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(oct-1-ynyl)phenyl)-4-phenylpyrimidine(1428188-07-1)
• EPA Substance Registry System: 2-(3-(oct-1-ynyl)phenyl)-4-phenylpyrimidine(1428188-07-1)

Safety Data

• Hazardous Substances Data: 1428188-07-1(Hazardous Substances Data)

Upstream product

• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 629-05-0 n-octyne 
• 16796-52-4 3-bromobenzene-1-carboximidamide hydrochloride 

Relevant articles and documents

One-pot, three-component synthesis of novel 4-phenyl-2-[3-(alkynyl/alkenyl/ aryl)phenyl]pyrimidine libraries via michael addition, cyclization, and C-C coupling reactions: A new MCR strategy

Privileged medicinal scaffolds based on the structures of 4-phenyl-2-[3-(alkynyl/alkenyl/aryl)phenyl]-substituted pyrimidines have been synthesized via a single-step, three-component reaction of 3-(dimethylamino)-1- phenylprop-2-en-1-one (enaminone), 3-bromobenzimidamide hydrochloride, and various alkynes/alkenes/arylboronic acids. The mechanism of this multi-component reaction (MCR) involves a Michael addition, cyclization, isomerization, and dehydration, followed by Sonogashira, Heck or Suzuki coupling. This new MCR strategy afforded a new compound library based on pyrimidine framework. Georg Thieme Verlag Stuttgart · New York.