1428247-44-2Relevant academic research and scientific papers
N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections
Du, Yanming,Ye, Hong,Gill, Tina,Wang, Lijuan,Guo, Fang,Cuconati, Andrea,Guo, Ju-Tao,Block, Timothy M.,Chang, Jinhong,Xu, Xiaodong
, p. 2172 - 2176 (2013/04/23)
Novel N-alkyldeoxynojirimycins (NADNJs) with two hydrophobic groups attached to a nitrogen linker on the alkyl chain were designed. A novel NADNJ containing a terminal tertiary carboxamide moiety was discovered that was a potent inhibitor against BVDV. Further optimization resulted in a structurally more stable lead compound 24 with a submicromolar EC50 against BVDV, Dengue, and Tacaribe; and low cytotoxicity.
