1428331-43-4Relevant academic research and scientific papers
In vitro evolution of a Friedel-Crafts deoxyribozyme
Mohan, Utpal,Burai, Ritwik,McNaughton, Brian R.
, p. 2241 - 2244 (2013)
We report the in vitro selection of a single-stranded 72-nucleotide DNA enzyme (deoxyribozyme) that catalyzes a Friedel-Crafts reaction between an indole and acyl imidazole in good yield and in aqueous solvent. Appreciable Friedel-Crafts product requires addition of copper nitrate and the deoxyribozyme. We observe deoxyribozyme-mediated bond formation for both in cis and in trans Friedel-Crafts reactions.
