1428331-72-9Relevant articles and documents
Iron(II)-catalyzed benzylic fluorination
Bloom, Steven,Pitts, Cody Ross,Woltornist, Ryan,Griswold, Andrew,Holl, Maxwell Gargiulo,Lectka, Thomas
, p. 1722 - 1724 (2013)
Direct C-F functionalization of benzylic sp3 C-H bonds is a synthetic challenge that has yet to be propitiously overcome. A mild, one-pot synthesis of monofluorinated benzylic substrates is reported with commercially available iron(II) acetylacetonate and Selectfluor in good to excellent yields and selectivity. A convenient route to β-fluorinated products of 3-aryl ketones is also highlighted, providing a synthetic equivalent to the difficult to accomplish conjugate addition of fluoride to α,β-unsaturated ketones.