1428340-13-9

Basic information

• Product Name: C₁₀H₉N₃O
• Synonyms: C₁₀H₉N₃O
• CAS NO: 1428340-13-9
• Molecular Weight: 187.201
• Mol File: 1428340-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₉N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₉N₃O(1428340-13-9)
• EPA Substance Registry System: C₁₀H₉N₃O(1428340-13-9)

Safety Data

• Hazardous Substances Data: 1428340-13-9(Hazardous Substances Data)

Upstream product

• 944468-99-9 6-chloro-4-phenyl-pyridazin-3-yl-amine 
• 6131-90-4 sodium acetate trihydrate 

Relevant articles and documents

Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors

The design and synthesis of pyridazinone and phthalazinone derivatives are described. Newly synthesized compounds were tested on a panel of four kinases in order to evaluate their activity and potential selectivity. In addition, the promising compounds were tested on four cancer cell lines to examine cytotoxic effects. The compounds inhibited DYRK1A and GSK3 with different activity. SAR analysis and docking calculations were carried out to aid in the interpretation of the results. Taken together, our findings suggest that pyridazinone and phthalazinone scaffolds are interesting starting points for design of potent GSK3 and DYRK1A inhibitors.