1428366-48-6

Basic information

• Product Name: C₂₁H₂₅NOS
• CAS NO: 1428366-48-6
• Molecular Weight: 339.502
• Mol File: 1428366-48-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₅NOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₅NOS(1428366-48-6)
• EPA Substance Registry System: C₂₁H₂₅NOS(1428366-48-6)

Safety Data

• Hazardous Substances Data: 1428366-48-6(Hazardous Substances Data)

Upstream product

• 1428366-11-3 C₁₈H₂₂OS₂ 
• 1730-25-2 allylmagnesium bromide 
• 94265-89-1 bis(1-methyl-1-phenylethyl)disulfide 
• 16325-88-5 α,α-dimethylbenzylmercaptan 
• 1428365-94-9 (R_s)-2-phenylpropyl-2-sulfinamide 
• 1428366-12-4 C₁₅H₂₇NOSSi 

Relevant articles and documents

Design, synthesis, and applications of chiral N-2-phenyl-2-propyl sulfinyl imines for group-assisted purification (GAP) asymmetric synthesis

A new chiral (Rs)-2-phenyl-2-propyl sulfinamide has been designed and synthesized; its derived aldimines and ketimines have been applied for asymmetric addition reaction with allylmagnesium bromide. The reaction was conveniently performed at room temperature to give a series of homoallylic amines in high yields (up to quant) and diastereoselectivity (up to >99% de). The pure products were obtained by relying on group-assisted purification (GAP) chemistry to avoid traditional purification methods of column chromatography or recrystallization. The conversion of disulfide to (Rs)-thiosulfinate which contains a newly generated polar group was also confirmed to be of the GAP chemistry in which washing crude product can generate pure enantiomer. The absolute stereochemistry has been determined by X-ray analysis.