1428368-48-2Relevant academic research and scientific papers
Oxidative annulations via double C-H bond cleavages: Approach to quinoline derivatives
Liu, Zhenghui,Guo, Shien,Wang, Peng,Yan, Zhenzhong,Mu, Tiancheng
, (2021)
An approach to complicated quinoline derivatives catalyzed by rhodium catalytic system via oxidative annulations was proposed. A systematic exploration was completed. All kinds of reaction parameters were determined. And 55 kinds of target molecules were obtained with moderate to high yields. Combination of double oxidants made the conversion proceed smoothly. A clear reaction mechanism was put forward. Adjacent π systems might provide assistance for realizing the activation of relatively unreactive C(5)-H of imidazole rings by forming five-membered metallacycle intermediates. In addition, scaled-up experiment verified the practical applicability.
Rhodium(III)-catalyzed direct selective C(5)-H oxidative annulations of 2-substituted imidazoles and alkynes by double C-H activation
Huang, Ji-Rong,Zhang, Qian-Ru,Qu, Chuan-Hua,Sun, Xun-Hao,Dong, Lin,Chen, Ying-Chun
supporting information, p. 1878 - 1881 (2013/05/23)
Double C-H activations of C(5)-H and Csp2-H of 2-substituted N-vinyl- or arylimidazoles were realized without heteroatom-directing assistance by rhodium(III) catalyst. A subsequent oxidative annulation reaction with alkynes efficiently produced aza-fused heterocycles with high molecular complexity in low to excellent yields.
