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1428382-55-1

(E)-16-(4-methylphenyl)methylidene-trans-dehydroandrosterone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1428382-55-1 Structure

  • Basic information

    1. Product Name: (E)-16-(4-methylphenyl)methylidene-trans-dehydroandrosterone
    2. Synonyms: (E)-16-(4-methylphenyl)methylidene-trans-dehydroandrosterone
    3. CAS NO:1428382-55-1
    4. Molecular Formula:
    5. Molecular Weight: 390.566
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1428382-55-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-16-(4-methylphenyl)methylidene-trans-dehydroandrosterone(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-16-(4-methylphenyl)methylidene-trans-dehydroandrosterone(1428382-55-1)
    11. EPA Substance Registry System: (E)-16-(4-methylphenyl)methylidene-trans-dehydroandrosterone(1428382-55-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1428382-55-1(Hazardous Substances Data)

1428382-55-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1428382-55-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,8,3,8 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1428382-55:
(9*1)+(8*4)+(7*2)+(6*8)+(5*3)+(4*8)+(3*2)+(2*5)+(1*5)=171
171 % 10 = 1
So 1428382-55-1 is a valid CAS Registry Number.

1428382-55-1Downstream Products

1428382-55-1Relevant articles and documents

Synthesis of novel 16-spiro steroids: Spiro-7′-(aryl)tetrahydro-1H- pyrrolo[1,2-c][1,3]thiazolo-trans-androsterone hybrid heterocycles

Kanchithalaivan, Selvaraj,Kumar, Raju Ranjith,Perumal, Subbu

, p. 409 - 417 (2013)

The 1,3-dipolar cycloaddition of azomethine ylide derived in situ from the reaction of acenaphthylene-1,2-dione and 1,3-thiazolane-4-carboxylic acid to various exocyclic dipolarophiles synthesized from trans-androsterone and trans-dehydroandrosterone afforded a library of novel spiro[5′.2″] acenaphthylene-1″-one-spiro[16.6′]-(7′-aryl) -tetrahydro-1H-pyrrolo [1,2-c][1,3]thiazolo-trans-androsterone/ dehydroandrosterone hybrid heterocycles respectively. These reactions proceeded stereo-specifically affording a single isomer of the 16-spiro steroids in excellent yields.

Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents

Yu, Bin,Shi, Xiao-Jing,Qi, Ping-Ping,Yu, De-Quan,Liu, Hong-Min

, p. 121 - 134 (2014/03/21)

Two series of novel steroidal spiro-pyrrolidinyl oxindoles 3a-t and 6a-c were designed and synthesized from dehydroepiandrosterone using the 1,3-dipolar cycloaddition as the key step and further evaluated for their antiproliferative activities for four human cancer cell lines (MGC-803, EC109, SMMC-7721 and MCF-7). This protocol achieved the formation of two CC bonds, one CN bond and the creation of one new five-membered pyrrolidine ring and three contiguous stereocenters in a single operation. Biological evaluation showed that these synthesized steroidal spiro-pyrrolidinyl oxindoles possessed moderate to good antiproliferative activities against the tested cell lines and some of them were more potent than 5-Fu. Particularly, compound 3g showed good antiproliferative activity against SMMC-7721 (IC50 = 0.71 μM). Steroid dimer 6b showed improved antiproliferative activities against SMMC-7721 and MCF-7 with the IC50 values of 4.30 and 2.06 μM, respectively. Flow cytometry analysis demonstrated that compound 3n caused the cellular early apoptosis and cell cycle arrest at G2/M phase in a concentration- and time-independent manner.

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