1428478-75-4

Upstream product

• 1428478-74-3 tert-butyl 4-[2-(4-aminophenyl)-1-hydroxyethyl]piperidine-1-carboxylate 
• 122-51-0 orthoformic acid triethyl ester 
• 1428478-73-2 tert-butyl 4-{2-[4-(acetylamino)phenyl]-1-hydroxyethyl}piperidine-1-carboxylate 
• 1428478-72-1 tert-butyl 4-{[-4-(acetylamino)phenyl]acetyl}piperidine-1-carboxylate 
• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1428478-71-0 tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate 

Downstream Products

• 1428478-70-9 1-(piperidin-4-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanol 
• 1428477-74-0 5-[2-(4-{1-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one 
• 1428477-75-1 5-[2-(4-{(1S)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one 
• 1428477-76-2 5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one 
• 1428477-91-1 5-[2-(4-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one 

Relevant academic research and scientific papers

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

no abstract published

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kirl.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure